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Home - Products - Nuclear Receptor/Transcription Factor - Keap1-Nrf2 - Tigloylgomisin H

Tigloylgomisin H

CAS No. 66069-55-4

Tigloylgomisin H( —— )

Catalog No. M29235 CAS No. 66069-55-4

Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Tigloylgomisin H
  • Note
    Research use only, not for human use.
  • Brief Description
    Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells.
  • Description
    Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway and can be used in liver cancer prevention studies.(In Vitro):Tigloylgomisin H (TGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) of 10.80 as compared to control. Tigloylgomisin H also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, Tigloylgomisin H significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    Keap1-Nrf2
  • Recptor
    Nrf2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    66069-55-4
  • Formula Weight
    500.59
  • Molecular Formula
    C28H36O8
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1cc2C[C@H](C)[C@@](C)(O)Cc3cc(OC)c(OC)c(OC)c3-c2c(OC(=O)C(\C)=C\C)c1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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